PARP inhibitors are a group of inhibitors targeting poly(ADP-ribose) polymerases (PARP1 or PARP2) involved in DNA repair......

Homologous recombination(HR)is one of major mechanisms that repair DNA double strand breaks(DSBs)and helps maintain geno......

聚腺苷二磷酸核糖聚合酶(PARP)是一类在真核细胞中高表达的核酶，在DNA损伤修复中起关键作用。近年来，PARP抑制剂在肿瘤治疗中显示出......